APOE and complement C4 gene expression

Biomarker1 paper2 findings

  • Humans1

Interventions

2

Levetiracetam

downin human cells1Low certainty

1 study

  1. Levetiracetam decreases APOE and complement C4 gene expression in human cells.

    CellshiPSC-derived astrocyte

    Genetic risk scores linked to faster progression to Alzheimer’s · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Oct 2026

Levetiracetam →

Estradiol

downin human cells1Low certainty

1 study

  1. Estradiol decreases APOE and complement C4 gene expression in human cells.

    CellshiPSC-derived astrocyte

    Genetic risk scores linked to faster progression to Alzheimer’s · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Oct 2026

Estradiol →

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11
Alzheimer's & DementiaHumans

Genetic risk scores linked to faster progression to Alzheimer’s

In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over…In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over time, of 1.25 to 2.02.

Alzheimer's disease

Related