What does the research say about alternative junction use relative to principal junctions?

Alternative junction use relative to principal junctions

There is 1 paper on alternative junction use relative to principal junctions in aging research: none in people yet. The newest story, Nov 9, 2026: “Age-linked RNA processing differs in human brain and body”.

Biomarker

1 paper studies it1 finding

1 new paper in 30 daysSee all 1 papers on alternative junction use relative to principal junctions

“In brain, testable alternatives decreased relative to their principal reference about twice as often as they increased (31% increasing), and unannotated alternatives more so (12%).”

Older and Younger Splicing Across 49 Human TissuesPreprints.org2026doi:10.20944/preprints202611.0551.v1

In silico1

Associations

Older donor age

downin humans1

1 study

Older donor age is associated with alternative junction use relative to principal junctions in humans (31% of testable alternatives increasing; 12% of unannotated alternatives increasing).
“In brain, testable alternatives decreased relative to their principal reference about twice as often as they increased (31% increasing), and unannotated alternatives more so (12%).”
Humansbrain
Age-linked RNA processing differs in human brain and body
Preprints.orgNov 5, 2026Preprint

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1 paper in 12 months

Preprints.orgNov 7

Age-linked RNA processing differs in human brain and body

The spread of age-linked effects at the same RNA joining sites was 2.0–2.8 times as wide in brain as in body tissues from the same donors.The spread of age-linked effects at the same RNA joining sites was 2.0–2.8 times as wide in brain as in body tissues from the same donors.

Preprint: cross-sectional studyMechanisms

Paper

Alternative junction use relative to principal junctions

Associations

Latest

Age-linked RNA processing differs in human brain and body

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