19-protein signature

1. 19-protein signature predicts bone loss in humans (C-statistic 0.83 vs 0.58 (CTX) and 0.54 (P1NP)).

   “A 19-protein signature was much more strongly predictive of bone loss than traditional bone remodeling markers (C statistics: signature - 0.83, CTX – 0.58, P1NP – 0.54).”

   Humansserum∼6 yrsmalesn = 230

   Proteomics of HRpQCT Bone Loss in Older Men

   GSA 2025 abstract·31 Dec 2025

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