[11C]UCB-J DVR

1. [11C]UCB-J DVR has no effect on premorbid IQ in humans.

   “DVR was not significantly associated with current or premorbid IQ in either group”

   Humanswhole brain grey matter

   Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [¹¹C]UCB-J positron emission tomography study

   Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·3 Feb 2026

1. Schizophrenia decreases [11C]UCB-J DVR in humans (Cohen's d = 0.64, p = 0.01).

   “Whole brain grey matter [11C]UCB-J distribution volume ratio (DVR) was significantly lower in the SCZ than the HV group (Cohen's d = 0.64, p = 0.01)”

   Humanswhole brain grey matter

   Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [¹¹C]UCB-J positron emission tomography study

   Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·3 Feb 2026

More on Schizophrenia

1. age is associated with [11C]UCB-J DVR in humans (Spearman's rho = -0.46 to -0.55).

   “negatively correlated with age in both groups (Spearman's rho = -0.46 to -0.55)”

   Humanswhole brain grey matter

   Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [¹¹C]UCB-J positron emission tomography study

   Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·3 Feb 2026