Gianrico Farrugia

Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice

Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal…Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.