Shashank Shekhar

Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease

A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.