Jie Zhu
Chinese Academy of Sciences1 paperORCID 0000-0002-7144-0471OpenAlex
Papers
Advanced ScienceAnimals
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice
The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.