Isaac F. López-Moyado

TET deficiency drives selection of aneuploid cells in mice

In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.