No phaseRecruitingAge-related condition

Effects of vascular occlusion with aerobic exercise in older people with muscle weakness

Effects of blood flow restriction associated with aerobic training: physical, cognitive and biomolecular outcomes in older people with sarcopenia

Sponsor: Faculdade de Medicina da Universidade de São Paulo
Enrolment: 38 planned
Conditions: Sarcopenia Pathological Conditions, Signs and Symptoms
Interventions: This is a two-arm, double-blind, randomized controlled trial; two weeks at 50% AOP; two weeks at 60% AOP; two weeks at 70% AOP; four weeks at 80% AOP); 4 weeks of 3x12 repetitions; and 4 weeks of 4x12 repetitions)
Ages: adults, older adults
Registry: RBR-9sjzd7x

Full record on ReBECSource: WHO ICTRP, processed 14 September 2026

Primary outcomes

To assess the maximum isometric strength of the quadriceps femoris muscle, measured in kilogram-force using a portable digital dynamometer at the start of the study, after 12 weeks (post-intervention), and after 24 weeks (12-week post-intervention follow-up)
To assess lower limb functional performance (primary outcome), as determined by the time in seconds taken to complete the sit-to-stand test five times, at the start of the study, after 12 weeks (post-intervention), and after 24 weeks (12-week post-intervention follow-up)
To assess overall muscle strength, measured in kilogram-force using a manual hydraulic dynamometer, at the start of the study, after 12 weeks (post-intervention), and after 24 weeks (12-week post-intervention follow-up)
Assess the maximum isometric strength of the biceps brachii muscle, measured in kilogram-force using a portable digital dynamometer at the start of the study, after 12 weeks (post-intervention), and after 24 weeks (12-week post-intervention follow-up)