Phase 2CompletedAge-related condition
Comparison of the Therapeutic Effects of Lyophilized Platelet-rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis
- Sponsor
- Taichung Veterans General Hospital (Academic or other)
- Enrolment
- 39 enrolled
- Conditions
- Knee Osteoarthritis; Platelet-rich Plasma (PRP)
- Interventions
- Lyophilized Platelet-rich Plasma Lysate; Dextrose Prolotherapy
- Ages
- adults, older adults
- Registry
- NCT07875543
Full record on ClinicalTrials.gov
From the registry
The goal of this clinical trial is to compare the therapeutic effects of lyophilized platelet-rich plasma lysate and dextrose prolotherapy in patients with knee osteoarthritis (OA). The main questions it aims to answer are: * Does lyophilized platelet-rich plasma lysate improve pain, physical function, and muscle strength in patients with knee osteoarthritis? * Is lyophilized platelet-rich plasma lysate more effective than dextrose prolotherapy in improving clinical outcomes in patients with knee osteoarthritis? Researchers will compare patients receiving lyophilized platelet-rich plasma lysate with those receiving dextrose prolotherapy to evaluate differences in treatment effectiveness. Participants will: * Receive intra-articular injections of either lyophilized platelet-rich plasma lysate or dextrose prolotherapy. * Undergo clinical assessments before and after treatment, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to evaluate pain, stiffness, and physical function. * Undergo knee X-ray examinations to assess osteoarthritis severity…
Primary outcomes
- Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score from Baseline
History
Registered
Primary completion
Started