Effect of Two Weeks of Low-Dose Apixaban on Platelet Reactivity in Patients With Stable Coronary Artery Disease on Dual Antiplatelet Therapy (Aspirin and Clopidogrel) (ACER)

The goal of this clinical trial is to learn whether a low dose of apixaban, a blood-thinning medicine, changes how active the platelets are in adults with stable coronary artery disease who are already taking aspirin and clopidogrel. Platelets are small blood cells that help form clots. Aspirin and clopidogrel are used to keep platelets from clumping and to lower the risk of heart attack and stroke. In some people, however, platelets stay very active even while taking these medicines, which raises the risk of future heart problems. Apixaban works on a different part of the clotting process, and researchers want to find out whether it lowers platelet activity further. The main questions it aims to answer are: Does taking low-dose apixaban for 14 days lower platelet activity, as measured by the VerifyNow P2Y12 test (reported as P2Y12 reaction units, or PRU)? Does low-dose apixaban change how platelets respond to aspirin, as measured by the VerifyNow aspirin test (reported as aspirin reaction units, or ARU)? Is 14 days of low-dose apixaban, added to aspirin and clopidogrel, safe and…

• Change in P2Y12 Reaction Units (PRU) From Baseline to Day 14

1. Study completion expected

   1 Oct 2028

2. Primary completion expected

   1 Oct 2027

3. Registered

   2 Oct 2026

4. Started

   3 Sept 2026