Early Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults (ePROFILE20)

This study is a pre-post, open-label pilot feasibility study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults. Participants will take one capsule daily for 1 month. During the study, participants will complete online cognitive tasks and provide blood and stool samples collected during home visits by trained staff. The samples will be analysed to explore changes in gut bacteria and other biological markers. This study aims to understand whether the supplement is well tolerated and whether measurable biological changes occur. The study does not involve any experimental drugs or invasive procedures beyond blood sampling and stool collection, and participants will not be asked to change any current prescribed medications or treatments; with eligibility exclusions applying for recent antibiotics or immunosuppressants. The supplement is being studied for research purposes only and is not intended to diagnose, treat, or prevent disease.

• Stool metagenome

1. Study completion expected

   1 Sept 2027

2. Primary completion expected

   1 Jun 2027

3. Expected to start

   1 Jan 2027

4. Last registry update

   9 Oct 2026

5. Registered

   25 Sept 2026