No phaseNot yet recruiting

Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia (DENTIS-PSD)

Individualized Transcranial Temporal Interference Stimulation Targeting the Dentato-Thalamo-Cortical Pathway for Post-Stroke Dysphagia: A Randomized, Double-Blind, Sham-Controlled Trial

Sponsor
Zhejiang University (Academic or other)
Enrolment
112 planned
Conditions
Deglutition Disorders; Ischemic Stroke
Interventions
Active Transcranial Temporal Interference Stimulation; Sham Transcranial Temporal Interference Stimulation; Standardized Task-Specific Swallowing Rehabilitation
Ages
adults, older adults
Registry
NCT07766668

From the registry

The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke. It will also evaluate the safety and tolerability of this stimulation. The main questions it aims to answer are: * Does active temporal interference stimulation combined with swallowing rehabilitation improve swallowing safety more than sham stimulation combined with the same rehabilitation? * What side effects or medical problems occur during and after the stimulation? Researchers will compare active stimulation with sham stimulation, which uses the same equipment but does not deliver sustained therapeutic stimulation. Participants will: * Receive active or sham stimulation for 30 minutes per session, 5 days per week for 2 weeks * Receive the same task-specific swallowing rehabilitation after each stimulation session * Undergo swallowing assessments, brain imaging, and neurophysiological testing * Attend follow-up assessments 4 and 12 weeks after treatment

Primary outcomes

  • Post-treatment Penetration-Aspiration Scale (PAS) score
Full record on ClinicalTrials.gov