Home-Based High-Intensity Interval Training in Systemic Lupus Erythematosus (MIGHT-SLE)

Systemic lupus erythematosus, or SLE, is a chronic autoimmune disease that can cause persistent fatigue, muscle pain, reduced physical function, and impaired quality of life, even when the disease is otherwise clinically stable. The biological mechanisms contributing to these symptoms are not fully understood. Abnormal energy production within skeletal muscle and increased fat accumulation within the muscle may contribute to fatigue and reduced physical performance in people with SLE. This pilot study will evaluate the effects of a 16-week personalized, home-based exercise program in 20 adults with stable SLE and clinically significant fatigue. The program will include three exercise sessions per week: bodyweight high-intensity interval training, strength training, and walking-based interval training. Sessions will be adapted to each participant's fitness, mobility, symptoms, and exercise tolerance. Some sessions will be supervised remotely by video, while others will be completed independently using personalized recorded instructions. Participants will undergo assessments before…

• Change From Baseline in Phosphocreatine Recovery Half-Time at Week 16
• Change From Baseline in Thigh Intermuscular Adipose Tissue at Week 16

1. Study completion expected

   Sept 2029

2. Primary completion expected

   Nov 2027

3. Expected to start

   Dec 2026

4. Last registry update

   13 Oct 2026

5. Registered

   21 Jul 2026