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Weight Loss Composition and Metabolic Adaptation During Hypocaloric Dieting
The Relationship Between Weight Loss Composition, Body Composition Changes, and Metabolic Adaptation During a Hypocaloric Dietary Intervention
- Sponsor
- Tel Aviv University (Academic or other)
- Enrolment
- 150 planned
- Conditions
- Obesity
- Interventions
- Hypocaloric Diet
- Ages
- adults, older adults
- Registry
- NCT07627256
Full record on ClinicalTrials.gov
From the registry
Weight loss induced by hypocaloric dietary interventions is commonly accompanied by reductions in resting metabolic rate (RMR), a phenomenon often described as metabolic adaptation. The magnitude of this decline varies substantially between individuals and may depend not only on the amount of weight lost but also on the composition of weight loss, particularly the relative contributions of fat mass and fat-free mass. This prospective interventional study will investigate whether changes in body composition during a hypocaloric dietary intervention are associated with changes in RMR and metabolic adaptation. Approximately 150 adults with overweight or obesity will participate in a structured dietary program designed to induce moderate energy restriction. Body composition and resting metabolic rate will be assessed before and after the intervention to evaluate associations between fat mass loss, fat-free mass loss, and metabolic responses to weight reduction.
Primary outcomes
- Change in Resting Metabolic Rate
History
Primary completion expected
Expected to start
Last registry update
Registered