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Phase 4Not yet recruitingHealthspan endpoint

Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

Sponsor
Peking University First Hospital (Academic or other)
Enrolment
1,996 planned
Conditions
Older Patients; Surgery; Dexmedetomidine; Esketamine; Transcranial Direct Current Stimulation; Cognitive Function; Survival
Interventions
Dex-Esk; Placebo; Active tDCS; Sham tDCS
Ages
older adults
Registry
NCT07576543

Full record on ClinicalTrials.gov

From the registry

Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes. An ongoing 2×2 factorial trial conducted by the investigators plan to test the effects of perioperative dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS) on postoperative neurocognitive complications in older patients. This long-term follow-up of the ongoing trial aims to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on long-term outcomes in older patients after noncardiac surgery.

Primary outcomes

  • Incidence of postoperative neurocognitive disorders (pNCD) at 3 months

History

  1. Study completion expected

  2. Primary completion expected

  3. Started

  4. Last registry update

  5. Registered