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Phase 4Not yet recruitingHealthspan endpoint

Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

Sponsor
Peking University First Hospital (Academic or other)
Enrolment
1,996 planned
Conditions
Older Patients; Surgery; Dexmedetomidine; Esketamine; Transcranial Direct Current Stimulation; Perioperative Neurocognitive Disorders
Interventions
Dex-Esk; Placebo; Active tDCS; Sham tDCS
Ages
older adults
Registry
NCT07576517

Full record on ClinicalTrials.gov

From the registry

Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse outcomes. In previous studies, perioperative use of dexmedetomidine-esketamine combination improved analgesia and sleep quality after surgery. Perioperative use of transcranial direct current stimulation (tDCS) also improved sleep quality and reduced delirium occurrence early after surgery. This 2×2 factorial trial is designed to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on delirium occurrence and early postoperative neurocognitive recovery in older patients.

Primary outcomes

  • Incidence of postoperative delirium (POD)

History

  1. Study completion expected

  2. Primary completion expected

  3. Started

  4. Last registry update

  5. Registered