No phaseRecruitingAge-related condition
HoLEP-ThuLEP - Comparing Lasers for BPH Surgery (HOT)
Prospective Randomized Comparative Study Evaluating Functional and Perioperative Outcomes After Thulium Laser Enucleation of the Prostate (ThuLEP) Versus Holmium Laser Enucleation of the Prostate (HoLEP)
- Sponsor
- Ludwig-Maximilians - University of Munich (Academic or other)
- Enrolment
- 150 planned
- Conditions
- BPH (Benign Prostatic Hyperplasia)
- Interventions
- Thulium Laser Enucleation of the Prostate (ThuLEP); Holmium Laser Enucleation of the Prostate (HoLEP)
- Ages
- adults, older adults
- Registry
- NCT07565961
Full record on ClinicalTrials.gov
From the registry
Benign prostatic hyperplasia (BPH) is a very common condition in older men. As the prostate enlarges, it can press on the urethra and make urination difficult. Typical symptoms include a weak urinary stream, frequent urination, getting up at night to urinate, and a feeling that the bladder is not fully empty. When medication is no longer sufficient, surgical removal of the inner part of the prostate ("enucleation") is the recommended treatment. Two modern laser techniques are used for this operation. Holmium Laser Enucleation of the Prostate (HoLEP) is currently considered the reference standard, with very good long-term results and a low rate of re-operations. Thulium Laser Enucleation of the Prostate (ThuLEP) using a pulsed thulium laser is a newer alternative. Because the laser energy is delivered in short pulses, ThuLEP may allow more precise tissue cutting and better control of bleeding during surgery. So far, only limited high-quality randomized data directly compare the two techniques, particularly for patient-reported outcomes such as urinary symptoms, continence, and…
Primary outcomes
- Change in International Prostate Symptom Score (IPSS) at 12 months
History
Study completion expected
Primary completion expected
Last registry update
Started
Registered