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The Effects of Mango on Gut Health Markers
The Effects of Fresh Mango Consumption on Gut Permeability Markers and Short Chain Fatty Acid Production in Individuals With Prediabetes
- Sponsor
- Loma Linda University (Academic or other)
- Enrolment
- 31 planned
- Conditions
- Gut Health; LBP; Short Chain Fatty Acids; sCD14
- Interventions
- Mango
- Ages
- adults
- Registry
- NCT07559604
Full record on ClinicalTrials.gov
From the registry
This is an ancillary study of NCT06159543, which was a clinical trial that examined the effect of a 12-week 1.5 cups daily mango crossover intervention on cardiometabolic outcomes in individuals with prediabetes, male and female, and 40-60 years of age. The goal of this ancillary study is to test the effect of the mango intervention on gut health markers in individuals with prediabetes. The main questions it aims to answer are: 1. What is the effect of 1.5 cups per day of fresh mango over 12 weeks on indicators of gut permeability as measured by lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14)? 2. What is the effect of 1.5 cups per day of fresh mango over 12 weeks on microbiome modulation as estimated by short chain fatty acids (SCFAs)? Secondarily: 1. Is LBP a mediator of the relationship between systemic inflammation \[as determined by C-reactive protein, E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)\] and SCFAs? 2. Is LBP a mediator of the relationship between insulin resistance \[as determined by…
Primary outcomes
- Lipopolysaccharide-binding protein (LBP)
- sCD14
- Short Chain Fatty Acids (SCFAs)
History
Study completion expected
Primary completion expected
Expected to start
Last registry update
Registered