No phaseNot yet recruiting
Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia
- Sponsor
- Johns Hopkins University (Academic or other)
- Enrolment
- 10 planned
- Conditions
- PPA
- Interventions
- Active tES; Cognitive Interventions
- Ages
- adults, older adults
- Registry
- NCT07511179
From the registry
This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with Primary Progressive Aphasia (PPA), addressing the inconsistent results of generic brain stimulation protocols. By integrating artificial intelligence (AI)-derived insights with real-time data, the study aims to customize transcranial electrical stimulation (tES) parameters, including electrode placement, intensity, and frequency to target the specific brain regions responsible for abnormal signaling in each participant. Over the intervention period paired with computerized cognitive training, the project will evaluate improvements in learning, memory, and functional connectivity, while simultaneously identifying clinical and physiological predictors to determine the viability of transitioning this low-cost, non-invasive technology into a remotely supervised, home-based therapy setting. The study duration will be a total of 6-8 weeks.
Primary outcomes
- Change in auditory recall accuracy based on the sum of words recalled in Trials 1-5 of semantically related - trained word-lists
- Change in auditory delayed recall accuracy of semantically related - trained word-lists
- Change in auditory recall accuracy based on the sum of words recalled in Trials 1-5 of semantically unrelated - trained word-lists
- Change in auditory delayed recall accuracy of semantically unrelated - trained word-lists