Phase 2Not yet recruiting
Effects of Meal Macronutrients on Postprandial Lipids
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (NIH)
- Enrolment
- 100 planned
- Conditions
- Nephrotic Syndrome; Lipodystrophy; Metabolic Syndrome; Healthy Volunteer; Diabetes; Metabolic Associated Steatotic Liver Disease
- Interventions
- High carb then high fat breakfast; High fat then high carb breakfast
- Ages
- adults, older adults
- Registry
- NCT07313787
From the registry
Background: Abnormal fats in the blood can lead to many problems, including heart disease. Researchers want to learn more about how eating meals with different levels of nutrients affects fats in the blood. Specifically, they want to study people with too much body fat, too little body fat, and a kidney problem called nephrotic syndrome. Objective: To learn more about how different types of foods affect fat levels in the blood. Eligibility: People aged 18 years or older with a health condition that affects how their body handles fats. Healthy volunteers are also needed. Design: Participants will have 2 overnight stays in the clinic within 6 months. At each visit, after staying overnight, they will eat a breakfast casserole. At 1 visit, breakfast will be a high-fat, low carbohydrate meal. At the other, it will be a high-carbohydrate, low-fat meal. Participants will have a tube inserted into a vein in their arm. They will have blood drawn via the tube 12 times in 8 hours: 2 times before they eat the breakfast and 10 times after. Participants will have other tests during their…
Primary outcomes
- Determine the difference in postprandial triglycerides between meals of different macronutrient composition within each study cohort.