Phase 2Recruiting
Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma (PNOC041)
A Target Validation and Efficacy Study of Metformin in Patients With Recurrent or Progressive Posterior Fossa Group A (PFA) Ependymoma
- Sponsor
- University of California, San Francisco (Academic or other)
- Enrolment
- 30 planned
- Conditions
- Posterior Fossa Ependymal Tumor
- Interventions
- Metformin; Planned Surgical Resection; Magnetic Resonance Imaging (MRI); Specimen Collection; MR spectroscopy (MRS)
- Ages
- children, adults
- Registry
- NCT07226453
From the registry
This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.
Primary outcomes
- Proportion of participants with changes in biomarkers between the pre-and post-metformin treated samples (Target Validation Phase)
- Disease Stabilization Rate (Efficacy Phase)