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Early phase 1Not yet recruiting

Vitamin C With Steroids for Gastrointestinal GVHD

Administration of Vitamin C (Ascorbic Acid) With Steroids for First Line Therapy of Gastrointestinal GVHD

Sponsor
Baylor College of Medicine (Academic or other)
Enrolment
35 planned
Conditions
Graft-versus-host-disease (GVHD); Gastrointestinal
Interventions
Vitamin C (Ascorbic Acid)
Ages
children, adults, older adults
Registry
NCT07197749

Full record on ClinicalTrials.gov

From the registry

After a transplant from another donor, one risk is graft versus host disease (GVHD) that happens because of differences between the donated cells (graft) and the patient's body cells (host). The new cells from the donor might see the body's cells as different and attack them. GVHD can be very serious and cause death. The standard first treatment for GVHD is corticosteroids but not all patients respond and in cases where they don't, they need to go onto other treatments that may or may not be effective. In addition, when GHVD involves the gut it can damage the cells of the gastrointestinal track causing long term problems such as abdominal pain and bowel disturbance. In laboratory studies giving a vitamin C has been able to protect the gastrointestinal cells and help them recover. In this trial the investigators would like to see if vitamin C can do the same thing when given with steroids in patients with GVHD. The standard first treatment for acute GVHD is corticosteroids but not all patients respond and in cases where they don't, they need to go onto other treatments that may or…

Primary outcomes

  • Primary Endpoint

History

  1. Study completion expected

  2. Primary completion expected

  3. Expected to start

  4. Last registry update

  5. Registered