Phase 3Recruiting
Topical Versus Injection PRP for Olfactory Dysfunction (TOP-IN)
Carrier-Assisted Topical Application Versus Intranasal Injection of Autologous Platelet-Rich Plasma for Olfactory Dysfunction: A Randomized Controlled Trial
- Sponsor
- Taipei Veterans General Hospital, Taiwan (Government)
- Enrolment
- 60 planned
- Conditions
- Olfactory Dysfunction; Anosmia; Hyposmia
- Interventions
- Intranasal Injection of Autologous PRP; Carrier-Assisted Topical Application of Autologous PRP; platelet-rich plasma; olfactory training
- Ages
- adults, older adults
- Registry
- NCT07151703
From the registry
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than three months. The main questions it aims to answer are: 1. Does carrier-assisted topical application of PRP lead to comparable or better improvement in smell function than intranasal injection of PRP? 2. Which method provides greater patient comfort and fewer adverse effects? Researchers will compare carrier-assisted topical PRP application to intranasal PRP injection to see if one approach is more effective in restoring olfactory function. Participants will: 1. Receive a single PRP treatment delivered either by injection or via a PRP-soaked carrier placed into the olfactory cleft. 2. Continue daily olfactory training for three months following the intervention. 3. Undergo smell testing (Sniffin' Sticks) before and after treatment and complete quality-of-life questionnaires.
Primary outcomes
- Sniffin' Sticks Olfactory Test