Early phase 1Recruiting
Effect of Neural Constraints on Movement in Stroke (ENCMS)
- Sponsor
- Northwestern University (Academic or other)
- Enrolment
- 64 planned
- Conditions
- Stroke
- Interventions
- Tizanidine; Placebo
- Ages
- adults, older adults
- Registry
- NCT06666673
From the registry
This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity kinematics, pupillometry, and brain activity. Tizanidine is approved by the U.S. Food and Drug Administration. Understanding how different areas of the brain are involved in movement impairments may help rehabilitation efforts and assist in restoring healthy movement in individuals who have had a stroke.
Primary outcomes
- Brace Height
- Cortico-muscular-coherence in beta band
- Difference in reaching distance under shoulder abduction load
- Reflexive electromyograph activity prior to movement