No phaseCompletedAge-related condition
Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes
- Sponsor
- Masaryk University (Academic or other)
- Enrolment
- 55 enrolled
- Conditions
- Aging; Mild Cognitive Impairment; Dementia With Lewy Bodies
- Interventions
- transcranial alternating current stimulation
- Ages
- adults, older adults
- Registry
- NCT06563453
Full record on ClinicalTrials.gov
From the registry
Cognitive reserve (CR) is defined as the gradual accumulation of neural resources and their adaptability (i.e., efficiency, capacity, flexibility) due to genetic and/or lifelong environmental factors that mitigate the cognitive effects of age-related processes and brain diseases. Transcranial alternating current stimulation (tACS) can be used to entrain underlying neuronal networks, promoting firing at specific frequencies. Recent studies have demonstrated that fronto-parietal theta oscillatory activity entrainment via tACS leads to working memory enhancement in healthy subjects. However, there remains significant variability in stimulation-induced aftereffects across individuals. Emerging literature suggests that individual differences, such as CR levels, may be crucial in predicting the benefits of treatment interventions, as they reflect available neural capacity and flexibility. A novel interventional approach is proposed to study CR, utilizing both conventional static proxies, such as premorbid intellect and educational attainment, and dynamic markers, including pupillometry,…
Primary outcomes
- Accuracy of the visual 2-back and 3-back tasks in tACS conditions
- Accuracy of the verbal 2-back and 3-back tasks after tACS
- Reaction times of the visual N-back task in tACS conditions
- Reaction times of the verbal N-back task after tACS
History
Last registry update
Study completion
Primary completion
Registered
Started