Phase 2/3Completed
Pediatric Oncology Nutrition Intervention Trial (POINT)
The Pediatric Oncology Interventional Nutrition Therapy (POINT) Trial: A Pilot Study
- Sponsor
- Corey Hawes (Academic or other)
- Enrolment
- 20 enrolled
- Conditions
- Pediatric Cancer; Nutrition Related Cancer; Nutrition Aspect of Cancer; Muscle Loss; Malnutrition, Child
- Interventions
- Oral Nutrition Supplement; Tube Feed; Cyproheptadine; Olanzapine; Standard of Care
- Ages
- children, adults
- Registry
- NCT06175273
Full record on ClinicalTrials.gov
From the registry
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a combination of disease burden, side effects of chemotherapy, and the intensity of cancer treatment. These patients are known to have an increased risk of infection, treatment-related toxicity, inferior clinical outcomes, and increased risk of mortality. Malnutrition may progress to cancer cachexia, characterized by anorexia, increased inflammation, decreased fat, and decreased muscle mass with subsequent weight loss, which is associated with decreased overall survival. The goal of the proposed research is to determine changes in body composition, weight status, and nutritional status between common nutrition interventions including oral nutrition supplements (ONS), appetite stimulants, and enteral nutrition (EN) among pediatric cancer patients. A secondary goal of this research is to utilize the findings to develop clinical nutrition guidelines for this patient population. The specific objective of the research proposed is to solve the lack of evidence to adequately treat nutritional deficits in…
Primary outcomes
- Body Composition
- Change in Body Composition Mid-Upper Arm
History
Results first posted
Last registry update
Primary completion
Started
Registered