Phase 1CompletedAge-related condition
Choline Effects - Pre-symptomatic AD
Testing Whether Choline Normalizes Lipid Metabolism in APOE4 Carriers
- Sponsor
- Paul E Schulz (Academic or other)
- Enrollment
- 15 enrolled
- Conditions
- Alzheimer Disease
- Interventions
- Choline
- Ages
- adults, older adults
- Registry
- NCT05880849
Full record on ClinicalTrials.gov
From the registry
The purpose of this study is to test the safety, tolerability, and effects of choline in people with increased risk of Alzheimer's Disease (AD), also known as pre-symptomatic AD. Choline is a dietary supplement, but is being investigated to see if it has any effects on the progression to AD.
Primary outcomes
- Changes in the fatty acid desaturation index (FADI) in the CSF following choline supplementation
- Changes in phosphatidylcholine (PC) in the CSF following choline supplementation
History
Last registry update
Study completion
Primary completion
Started
Registered
Papers citing this trial
- Effect of choline supplementation in presymptomatic APOE ε4 carriers: a pilot study
Alzheimer's & dementia (New York, N. Y.)
- Choline Supplementation for APOE4 Carriers to Prevent Alzheimer's
Zenodo (CERN European Organization for Nuclear Research)