No phaseCompleted
Depression, Aging, Stress and Heart Health Study (DASHH)
The Comorbidity of Depression and Cardiovascular Disease in Midlife Women: Investigating Novel Biological Pathways of Risk
- Sponsor
- University of North Carolina, Chapel Hill (Academic or other)
- Enrolment
- 41 enrolled
- Conditions
- Menopause; Depression; Heart Disease in Women; Stress
- Interventions
- Trier Social Stress Test
- Ages
- adults
- Registry
- NCT05570721
From the registry
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and their relationship may underlie the link between these illnesses. Findings will provide important insight into potential mechanisms by which depression during perimenopause may increase risk for CVD in midlife women, which will inform potential risk reduction and treatment strategies that can improve health outcomes in this population.
Primary outcomes
- Salivary aldosterone (pg/mL) levels at rest (before the stress task).
- Change in salivary aldosterone (pg/mL) levels in response to the stress task.
- Plasma aldosterone (pg/mL) levels at rest (before the stress task).
- Change in plasma aldosterone (pg/mL) levels in response to the stress task.