No phaseCompleted
Perioperative Personalized Blood Pressure Management: IMPROVE-multi
Effect of Personalized Perioperative Blood Pressure Management on Postoperative Complications and Mortality in High-risk Patients Having Major Abdominal Surgery: a Multicenter Prospective Randomized Controlled Interventional Clinical Trial
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf (Academic or other)
- Enrolment
- 1,272 enrolled
- Conditions
- Blood Pressure; Intraoperative Hypotension; Postoperative Complications; Surgery; Anesthesia
- Interventions
- Personalized blood pressure management
- Ages
- adults, older adults
- Registry
- NCT05416944
Full record on ClinicalTrials.gov
From the registry
Rates of major complications and mortality in the first weeks after surgery remain very high: postoperative mortality is still around 2% in central Europe and the United States. Postoperative deaths are a consequence of postoperative complications. Postoperative complications that are most strongly associated with postoperative death include acute kidney injury and acute myocardial injury. To avoid postoperative complications it is thus crucial to identify and address modifiable risk factors for complications. One of these modifiable risk factors may be intraoperative hypotension. Intraoperative hypotension is associated with major postoperative complications including acute kidney injury, acute myocardial injury, and death. It remains unknown which blood pressure value should be targeted in the individual patient during surgery to avoid physiologically important intraoperative hypotension. In current clinical practice, an absolute mean arterial pressure threshold of 65mmHg is used as a lower "one-size-fits-all" intervention threshold. This "population harm threshold" is based on…
Primary outcomes
- Composite outcome of major postoperative complications
History
Last registry update
Study completion
Primary completion
Started
Registered