No phaseActive, not recruiting
Sodium Lowering Vascular Effects Trial (SOLVE)
A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function
- Sponsor
- Tulane University (Academic or other)
- Enrolment
- 256 enrolled
- Conditions
- Endothelial Dysfunction; Vascular Stiffness; Left Ventricular Hypertrophy; Left Ventricular Dysfunction
- Interventions
- Sodium Reduction Intervention
- Ages
- adults, older adults
- Registry
- NCT05388032
From the registry
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.
Primary outcomes
- Change in Left Ventricular Global Longitudinal Strain (LVGLS) from baseline to 12 months
- Change in Left Ventricular Mass Index (LVMI) from baseline to 12 months
- Change in Pulse Wave Velocity (PWV) from baseline to 12 months
- Change in Flow-Mediated Dilation (FMD) from baseline to 12 months