No phaseRecruiting
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
- Sponsor
- University of Alabama at Birmingham (Academic or other)
- Enrolment
- 200 planned
- Conditions
- Cardiovascular Diseases; Natriuretic Peptides; Cardiometabolic Diseases; Energy Expenditure; Glucose Metabolism; Exercise; Obesity
- Interventions
- Study diet; Exercise capacity VO2 max determination; Exercise Challenge; Glucose Challenge
- Ages
- adults, older adults
- Registry
- NCT05216042
From the registry
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.
Primary outcomes
- Change in MRproANP levels following a standardized oral glucose challenge between the high genotype group and low genotype group.
- Change in Exercise Energy Expenditure between the high genotype and low genotype group.
- Change in miR-425 levels following a standardized oral glucose challenge in those with low ANP genotype.
- Change in miR-425 levels following a standardized exercise challenge in those with low ANP genotype.