Phase 4Completed
MR Antagonist and LSD1
Role of LSD1 in Hypertension in Blacks
- Sponsor
- Brigham and Women's Hospital (Academic or other)
- Enrolment
- 300 enrolled
- Conditions
- Hypertension; Mineralocorticoid Excess
- Interventions
- Eplerenone; Amlodipine
- Ages
- children, adults, older adults
- Registry
- NCT04840342
From the registry
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new approach in treating a subset (\~30%) of the essential hypertension population (Black LSD1 risk allele hypertensives).
Primary outcomes
- 24-hour systolic ambulatory blood pressure