No phaseCompletedAge-related condition
Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis (BP-AVALVE)
- Sponsor
- Henrik Wiggers (Academic or other)
- Enrolment
- 60 enrolled
- Conditions
- Aortic Valve Stenosis; Hypertension,Essential; Heart Failure
- Interventions
- Blood presssure reduction
- Ages
- adults, older adults
- Registry
- NCT04613193
Full record on ClinicalTrials.gov
From the registry
The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis. The study is a randomized (1:1), open label, controlled intervention trial. Hypothesis: 1. Strict BP control for 12 months reduces the progression of LV remodelling compared to conventional treatment. 2. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment. 3. Strict BP reduction for up to 10 years reduces the need for aortic valve replacement and cardiovascular events compared to conventional care.
Primary outcomes
- Change in LV mass
- Change in aortic valve CT calcium volume and aortic peak gradient
- Clinical composite endpoint:
History
Last registry update
Study completion
Primary completion
Registered
Started