No phaseCompleted

Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging

Sponsor
University of Pittsburgh (Academic or other)
Enrolment
217 enrolled
Conditions
Urgency Urinary Incontinence
Interventions
Brain functional MRI with simplified urodynamics
Ages
adults, older adults
Registry
NCT04599088

From the registry

Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.

Primary outcomes

  • BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - mPFC
  • BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - Left Insula
  • BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - dACC
Full record on ClinicalTrials.gov