No phaseCompleted
Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
- Sponsor
- University of Pittsburgh (Academic or other)
- Enrolment
- 217 enrolled
- Conditions
- Urgency Urinary Incontinence
- Interventions
- Brain functional MRI with simplified urodynamics
- Ages
- adults, older adults
- Registry
- NCT04599088
From the registry
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
Primary outcomes
- BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - mPFC
- BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - Left Insula
- BOLD (Blood Oxygen Level Dependent) fMRI Signal Contrast - dACC