Phase 2Active, not recruiting
A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer (ADEPT)
20-347 NCT Number Title A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer (ADEPT)
- Sponsor
- Dana-Farber Cancer Institute (Academic or other)
- Enrolment
- 393 enrolled
- Conditions
- HER2-positive Breast Cancer; Invasive Carcinoma of the Breast; Breast Cancer; Node Negative Breast Cancer; Micrometastasis Breast Cancer; Hormone Receptor Positive Breast Cancer
- Interventions
- Pertuzumab+TRASTUZUMAB; ADJUVANT ENDOCRINE THERAPY
- Ages
- adults, older adults
- Registry
- NCT04569747
From the registry
This research study is studying a combination of HER2-directed therapies (trastuzumab and pertuzumab) and hormonal therapy as a treatment after surgery for hormone receptor positive breast cancer. The study drugs involved in this study are: * A combination of trastuzumab and pertuzumab given as an injection under the skin (PHESGO) * Hormonal (endocrine) Treatment
Primary outcomes
- Invasive Disease Free Survival at 3 Years