No phaseCompleted
Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients (OPTIMAL Stroke)
A Randomized Controlled Trial to Assess the Effect of Intensive Blood Pressure Control on Major Cardiovascular Events in Stroke Patients
- Sponsor
- Hospital Israelita Albert Einstein (Academic or other)
- Enrolment
- 4,368 enrolled
- Conditions
- Ischemic Stroke; Blood Pressure; Cognitive Impairment; Vascular Diseases
- Interventions
- Intensive Control of Systolic Blood Pressure (SBP); Standard control of Systolic Blood Pressure (SBP)
- Ages
- adults, older adults
- Registry
- NCT04036409
From the registry
Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events including stroke (which consists of the second leading cause of death in developing countries) and coronary artery disease, and is also related to cognitive decline. The OPTIMAL Stroke trial consists of a two-arm, multicenter, randomized clinical trial designed to test whether a lower target systolic blood pressure (SBP) as compared to the currently recommended target for stroke patients will reduce the occurrence of major cardiovascular events.
Primary outcomes
- Time to cardiovascular death, non-fatal myocardial infarction (MI), non-fatal stroke, hospitalization for unstable angina or hospitalization for heart failure [ Time Frame: From randomization; for approximately a mean of 3.5 years ]