Phase 4Completed
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement (PEPPER)
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement: Balancing Safety and Effectiveness
- Sponsor
- Dartmouth-Hitchcock Medical Center (Academic or other)
- Enrolment
- 18,883 enrolled
- Conditions
- Pulmonary Embolism; Venous Thrombosis
- Interventions
- Enteric Coated Aspirin; Warfarin; Rivaroxaban
- Ages
- adults, older adults
- Registry
- NCT02810704
From the registry
PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.
Primary outcomes
- Aggregate primary clinical endpoints of all-cause mortality plus PE and DVT
- The frequency and nature of bleeding complications
- Specific Joint Function
- Patient Well- Being