Phase 1CompletedAge-related condition
Bisnorcymserine in Healthy Adult Volunteers
Phase I, Double-Blind, Placebo-Controlled, Ascending, Single-Dose, Safety, Tolerability and Pharmacokinetic Study of Bisnorcymserine (BNC), a Highly Selective Inhibitor of Butyrylcholinesterase, in Healthy Adult Volunteers
- Sponsor
- National Institute on Aging (NIA) (NIH)
- Enrolment
- 75 enrolled
- Conditions
- Healthy Volunteers
- Interventions
- BNC; Placebo
- Ages
- adults, older adults
- Registry
- NCT01747213
Full record on ClinicalTrials.gov
From the registry
Background: \- Alzheimer s disease (AD) is a brain disease that impairs memory, cognitive abilities and the ability to function independently. It is the most common cause of dementia in older people. It is caused by abnormal proteins in the brain that affect how neurons communicate with each other. Researchers are looking for drugs that can slow down the disease or treat its symptoms. One drug, called bisnorcymserine (BNC), may help improve brain function and symptoms in people with AD. BNC is designed to block a chemical that affects how neurons communicate with each other. Researchers want to see how BNC works in healthy older volunteers. Objectives: \- To look at how the body processes bisnorcymserine taken by mouth and how safe it is for healthy older volunteers. Eligibility: \- Healthy volunteers at least 55 years of age. Design: * Participants will be screened with a physical exam, medical history, and blood and urine tests. * Within 3 weeks from the screening visit, participants will come to the National Institute on Aging clinical unit for a 2-night stay. On the…
Primary outcomes
- Safety and Tolerability
History
Last registry update
Study completion
Primary completion
Started
Registered