Phase 3CompletedHealthspan endpoint
DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
- Sponsor
- University of Zurich (Academic or other)
- Enrolment
- 2,157 enrolled
- Conditions
- Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
- Interventions
- Vitamin D3; Omega 3 fatty acids; Strength Home Exercise; Flexibility Home Exercise
- Ages
- older adults
- Registry
- NCT01745263
Full record on ClinicalTrials.gov
From the registry
The European population is aging rapidly which poses a challenge on the individual, the European societies, and health care systems. Among the most promising public health interventions that may extend healthy life expectancy at older age are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The broad aim of DO-HEALTH is to prolong healthy life expectancy in European seniors. The specific aim is to establish whether vitamin D, omega-3 fatty acids, and a simple home exercise program will prevent disease at older age. To achieve these aims, DO-HEALTH will enroll 2152 community-dwelling men and women who are 70 years and older, an age when chronic diseases increase substantially. The DO-HEALTH seniors will be recruited from 7 European cities (Zurich, Basel, Geneva, Toulouse, Berlin, Innsbruck and Coimbra) and will be randomized in a 2x2x2 factorial design trial to a simple home exercise program and/or vitamin D, and/or omega-3 fatty acids, over a 3 year period. This will allow to…
Primary outcomes
- Bone: Incident non-vertebral fractures over 36 months
- Muscle: Functional decline (lower extremity function)
- Cardio-vascular: Systolic and diastolic blood pressure change
- Brain: Cognitive decline
History
Last registry update
Study completion
Primary completion
Started
Registered