No phaseCompleted
Repetitive transcranial magnetic stimulation (rTMS) for fatigue in Parkinson's disease: a pilot study
Intermittent theta-burst stimulation for post-exercise recovery in Parkinson’s disease: a randomized, sham-controlled pilot crossover trial
- Sponsor
- Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (Academic or other)
- Enrolment
- 20 enrolled
- Conditions
- Parkinson's disease; physical (motor) fatigability.
- Interventions
- Magstim 200 stimulator with figure-8 coil (Magstim Company Ltd; Wales; UK); intermittent theta-burst stimulation (iTBS) protocol (Huang et al.; 2005)
- Ages
- adults, older adults
- Registry
- ISRCTN11453349
From the registry
Background and study aims Parkinson’s disease can cause unusual tiredness during physical activity. This is sometimes called physical fatigability. It may be linked not only to the muscles, but also to how the brain controls movement. This pilot study looked at recovery after tiring exercise in people with Parkinson’s disease and healthy people of a similar age. It also tested whether a non-invasive form of brain stimulation called intermittent theta-burst stimulation (iTBS) could help people recover after exercise. iTBS uses magnetic pulses to stimulate the part of the brain involved in controlling movement Who can participate? The study included people aged 40 to 75 years. People with Parkinson’s disease could take part if they had a confirmed diagnosis, had a stable positive response to Parkinson’s medication, and experienced fatigue related to their condition. Healthy volunteers of a similar age and sex could also take part if they did not have a medical condition or mental illness What does the study involve? A total of 20 people took part, including 10 people with Parkinson’s…
Primary outcomes
- Isometric maximal voluntary contraction (IMVC) of the biceps brachii
History
Registered
Study completion
Primary completion
Started