Papers by Yu Lin

45 results

  1. Biological Psychiatry Global Open Science

    Smoking links to dementia risk mainly in APOE ε4 noncarriers

    Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.

    Cohort study of 173,366 peopleAll-cause dementia
  2. Advanced Science

    Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice

    The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.

    Experiments in miceHuntington's disease