Papers by Lei Yu

9 results

  1. bioRxiv

    Dietary restriction activates autophagy through selective oxidation of ATG5

    Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.

    Preprint: experiments in miceAutophagy
  2. Nature Communications

    Microglial ALKBH5 loss protects fat browning in aging male mice

    Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.

    Experiments in miceMechanisms