Papers by Cheng Cheng

400+ results

  1. Aging Cell

    Higher birthweight and breastfeeding linked to slower organ aging

    In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.

    Cohort study of 29,713 peoplePopulations
  2. Environmental Health Perspectives

    Synthetic chemicals are linked to diabetes risk in women

    In a nested case-control study of 985 matched pairs, exposure to two common synthetic chemicals was linked to higher type 2 diabetes risk in women.In a nested case-control study of 985 matched pairs, exposure to two common synthetic chemicals was linked to higher type 2 diabetes risk in women.

    Case-control study in peopleType 2 diabetes
  3. Nature Neuroscience

    Genetic data highlight potential drug targets for Alzheimer's

    A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.

    Mendelian randomisation in 111,680 peopleAlzheimer's disease
  4. Free Radical Biology & Medicine

    Two PDE4 inhibitors extend lifespan in worms

    In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.

    Experiments in wormsInterventions
  5. Science

    Epigenetic aging runs faster in larger and male dogs

    An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex.An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex.

    Study of 894 dogsBiomarkers