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J. Graham Ruby

Works at

  • Calico

    Principal Investigatorcalicolabs.com

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    Direct AMPK activation modestly lengthens lifespan in short-lived species

    ResearchFight Aging!

    A protein complex with a bound molecule sits beside an unbound complex, with slightly more intact cells beneath the bound form and more fragments beneath the…

    Declining chaperone-mediated autophagy prevents macrophages from clearing senescent cells with age

    ResearchNature Aging and 1 more

    Senescence-inhibiting isoform Δ133p53α slows premature aging in mice

    Researchnpj Aging

    Figure 1

    Trials

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    Registered6 Oct 2026

    AKG and Brain Health in Aging

    Phase 2 · University of Oklahoma

    Registered2 Oct 2026

    Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)

    Phase 1 · Vinmec Research Institute of Stem Cell and Gene Technology

    Registered7 Oct 2026

    AI-Based Conversational Social Support for Older Adults With Heart Failure

    Chang Gung University of Science and Technology

    Trending

    Evidence →
    1. Intervention · 64 papersExercise
    2. Gene · 21 papersAPOE
    3. Disease · 122 papersCardiovascular disease
    4. Process · 117 papersInflammation
    5. Biomarker · 43 papersBody mass index
    6. Intervention · 42 papersGLP-1 receptor agonists

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