PET/CT Evaluation of Brain Aβ and Metabolism in a Marmoset Model of Alzheimer's Disease Based on Tau Seeding

Abstract

Background: Alzheimer’s disease (AD) is the leading form of dementia, affecting 7 million Americans over age 65. AD is characterized by the accumulation of amyloid‐β (Aβ) plaques in the brain and the formation of neurofibrillary tangles (NFT) of hyperphosphorylated tau. Aβ and tau accumulate in the brain decades before cognitive decline.

The paper