AAIC 2025 Abstract
Influence of APOEε4 on Blood Transcriptomics in Cognitively Impaired Individuals
By Marcelo Madrid de Bittencourt, Gabriela Mantovani Baldasso, Marco Antônio De Bastiani, Show 3 more authorsEduardo Rigon Zimmer
Study in peopleMechanisms
Abstract
Background: The APOEε4 allele is a well‐known genetic risk factor for sporadic Alzheimer's disease (AD). However, its influence on gene expression in peripheral blood remains underexplored. This study aimed to investigate the influence of the ε4 allele on blood gene expression in cognitively unimpaired (CU) and impaired (CI) individuals.
