Small Molecule of Secreted Clusterin Promotes Mitochondrial Function, Synaptic Plasticity and Improved Memory in an Alzheimer's Disease Mouse Model

Abstract

Background: Clusterin (CLU) is a key genetic risk factor for late‐onset Alzheimer’s disease (AD). Its secreted clusterin isoform (sCLU) is neuroprotective, promoting amyloid beta (Aβ) and tau clearance, reducing oxidative stress, and modulating immune responses, while the nuclear form (nCLU) is neurotoxic.

The paper