Impact of pTau‐Derived Cognitive Reserve on Alzheimer's Disease Progression

Abstract

Background: Alzheimer's disease (AD) follows a characteristic pathology where amyloid‐beta (Aβ) accumulation leads to tau hyperphosphorylation (pTau), neurodegeneration, and cognitive decline. While pTau is a key biomarker of AD progression, clinical outcomes vary among individuals with similar pathology.

The paper