Synergistic effect of APOE4 genotype and ELOVL2 methylation on cognitive slowing and verbal memory decline in non‐demented adults during aging

Abstract

Background: Aging plays a crucial role in exacerbating the negative impact of the APOE4 genotype on brain function, heightening the risk of Alzheimer disease (AD). Methylation of the ELOVL2 promoter is a robust epigenetic biomarkers of age.